| dc.contributor.author |
RANA, S. M. MASUD |
|
| dc.date.accessioned |
2024-01-29T03:42:26Z |
|
| dc.date.available |
2024-01-29T03:42:26Z |
|
| dc.date.issued |
2022-03 |
|
| dc.identifier.uri |
http://dspace.mist.ac.bd:8080/xmlui/handle/123456789/780 |
|
| dc.description |
First of all, thanks to Almighty ALLAH to whom I relate my success in my work. I thank my
supervisor, Major Md. Ashrafuzzaman, Ph. D, EME, for guiding me through this thesis and for
his great assistance, inspiration, advice, and encouragement.
The author would like to thank the Head of the Department for outstanding support and
encouragement during my thesis defense & seminar presentation.
The author would like to thank Khairul Islam who is the Scientist at Wazed Miah Science
Research Center, Jahangirnagar University for supporting FTIR and UV analysis. The author is
also thankful to Md. Habibur Rahman Previous student of the Pharmacy Department, Gono
Bishwabiddalay, and current Production Pharmacist of The ACME Laboratories Ltd., for his
outstanding support during wound healing test on mice model in Pharmacology Lab,
Jahangirnagar University.
The author like to thank the authority of the Chemistry Lab of Bangladesh University of
Engineering and Technology (BUET) for providing facility and support to the experiment using
Scanning Electron Microscope (SEM) and Armed Forces Institute of Pathology (AFIP) for
providing facility and support to the histological experiment.
The author is truly obliged to the rest of the members of my Board of Examination for reviewing
this thesis and giving me support, suggestions, and inputs to complete this thesis work.
At last, I would like to thanks my family who consistently supported and motivated me towards
achieving my goal. |
en_US |
| dc.description.abstract |
Ceramide is widely recognized for its skin barrier function whereas hydrogel is an ideal one for
wound healing where honey is used for antibacterial activity and burn wound treatment from
ancient ages. This research work proposes to develop a ceramide-loaded honey-based hydrogel
biomaterial for burn wound healing. The biodegradable hydrogels have been prepared by the
solution casting method. The developed hydrogel membranes were characterized by using
Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy
(FESEM), and UV Spectrophotometer. Besides that, swelling behavior in Physiological Solution,
Moisture Retention capability, Gel Fraction, Water Vapor Transmission Rate (WVTR), Porosity,
and Anti-microbial activity were studied and evaluated thoroughly. Then, ceramide hydrogel
(C2) and ceramide & honey Hydrogel (CH) were assessed for burn wound healing activity in the
mice model. Both C2 and CH hydrogel showed significant wound healing rates while only CH
hydrogel showed significant antibacterial activity against Staphylococcus aureus. Other
properties like physicochemical, swelling, WVT, porosity, gel fraction and data obtained from
FTIR, FESEM, and UV spectrophotometer were identical to confirm the presence of ceramide &
honey in the hydrogel. This newly prepared ceramide loaded honey based hydrogel plays an
important role during application on burn wounds and scars and further healing process. Current
outcomes of this research can be used for further investigation on the future biological assays to
declare this as a potent candidate for the treatment of burn patients. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Department of Biomedical Engineering, MIST |
en_US |
| dc.title |
DEVELOPMENT OF CERAMIDE AND HONEY BASED BIODEGRADABLE DRESSING MATERIALS FOR THE APPLICATION TO BURN SKIN |
en_US |
| dc.type |
Thesis |
en_US |
